學歷
 
State University of New York, Ph.D. (Biochemistry)
經歷  
2002-present Professor Institute of Biochemistry & Department od Life Science, National Yang-Ming University
Fields of Specialty  
  分子脢學、蛋白質結構與功能
 
學 術 研 究 著 作 ( Selected publication )

1. Chang, G. G., and Tong, L. (2003) Structure and function of malic enzymes, a new class of oxidative decarboxylases. Biochemistry 42, 12721-12733. (Current Topics)

2. Hung, H. C., Chen, Y. H., Liu, G. Y., Lee, H. J., and Chang, G. G. (2003) Equilibrium protein folding-unfolding process involving multiple intermediates. Bull. Math. Biol. 65, 553–570.

3. Chang, H. C., and Chang, G. G. (2003) Involvement of single residue tryptophan-548 in the quaternary structural stability of pigeon cytosolic malic enzyme. J. Biol. Chem. 278, 23996-24002.

4. Chen, Y. I., Chen, Y. H., Chou, W. Y., and Chang, G. G. (2003) Characterization of the interactions between Asp 141 and Phe 236 in the Mn2+-L-malate binding of pigeon liver malic enzyme. Biochem. J. 374, 633-637.

5. Kuo, C. W., Hung, H. C., Tong, L., and Chang G. G. (2004) Metal-induced reversible structural interconversion of human mitochondrial NAD(P)+-dependent malic enzyme. Proteins: Struct. Funct. Bioinfo. 54, 404-411.

6. Hsu, W. C., Hung, H. C., Tong, L., and Chang, G. G. (2004) Dual functional roles of ATP in human mitochondrial malic enzyme. Biochemistry 43, 7382-7390.

7. Chen, Y. H., Chang, T. C., and Chang, G. G. (2004) Functional expression, purification, and characterization of the extra stable human placental alkaline phosphatase in the Pichia pastoris system. Protein Express. Purif. 36, 90-99.

8. Chou, C. Y., Chang, H. C., Hsu, W. C., Lin, T. Z., Lin, C. H., and Chang, G. G. (2004) Quaternary structure of the severe acute respiratory syndrome (SARS) coronavirus main protease. Biochemistry 43, 14958-14970.

9. Chou, C. Y., Lin, Y. L., Huang, Y. C., Sheu, S. Y., Lin, T. H., Tsay, H. J., Chang, G. G., and Shiao, M. S. (2005) structural variance in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution. Biophys. J. 88, 455-466.

10. Hsu, W. C., Chang, H. C., Chou, C. Y., Tsai, P. J., Lin, P. I., and Chang, G. G. (2005) Critical assessment of important regions in the subunit association and catalytic action of the severe acute respiratory syndrome coronavirus main protease. J. Biol. Chem. 280, 22741-22748.

11. Chou, C. Y., Jen, W. P., Hsieh, Y. H., Shiao, M. S., and Chang, G. G. (2006) Structural and Functional Variations in Human Apolipoprotein E3 and E4. J. Biol. Chem. 281, 13333-13344.

12. Shen, Y., Chou, C. Y., Chang, G. G., and Tong. L. (2006) Is dimerization required for the catalytic activity of bacterial biotin carboxylase? Mol. Cell 22, 807-818.

13. Hsieh, J. Y., Liu, G. Y., Chang, G. G., and Hung, H. C.? (2006) Determinants of the dual cofactor specificity and substrate cooperativity of the human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of glutamine 362. J. Biol. Chem. 281, 23237-23245.